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SIAS Xantus ®

SIAS Xantus is a modular liquidhandlingsystem of hardware and
software modules. A full range of options and modules for liquid handling, detection, separation can be easily integrated with racks and carriers on the worktable allowing fast adaptation to ever changing needs.

The arm configuration can be chosen to optimize device access. You can even have a robotic manipulator arm. The arm can transport microplates to readers and plate washers, whether they are located on, beside or beneath the worktable and, if necessary, to a wide range of additional devices such as carousels, incubators or conveyors.

Total flexibility has been built into the Xantus. A open platform. that can be adapted easily to handle a wide range of applications. To match different throughput and capacity needs, the optimal worktable size may be selected from different lengths (100,150 and 200 cm).

SIAS Xantus, What's special - the Concept

Xantus is a truly modular state-of-the-art robotic system, combining refined, adaptable liquid handling with robotic manipulation.

No syringes mean:

Lower maintenance
Lower cost of maintenance
Wider range of liquids can be used
(DMSO, methanol etc.)

The robotic arm houses all of the fluidics components

Shorter distance between pumps
and tips for better fluidics control
Easy to upgrade & service
Less deck restriction - the rear of
the deck is completely open
allowing integration of additional
modules

Plug & play deck tray system

Simple, flexible, future-proof
All modules simply placed on or
lifted off for quicker & simpler
future upgrade options
Easily interchange modules for
optimal use of deck space
Greater configuration (& therefore
applications) flexibility
Easier to clean

Versatile liquid management

Variable tip spacing
Ultimate flexibility to handle
different vessel formats
Independent Z-axis control for
sample cherry picking
Superior speed with irregularly
spaced vessels

Liquid performance

means total control over all pipetting steps and movements.

Mixed washable needles & disposable tips

Zero sample carry-over when
needed (tips)
Rapid dispensing when needed
(needles)
Avoids unnecessary tip use, saves money

Independent liquid level sensors

Minimizes sample
carry-over
Reduces sample
wastage
Avoids pipetting errors
(missed samples)

Gripper Tool

Gripper rotates through 270°
Better use of deck space
Interface with other equipment
Gripper lift capability = 3kg
Move reaction blocks and other
heavy items
Gripper can reach outside worktable

Reagent & Sample Position

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Peltier temperature control of
reagent racks, 7 trays/ mtp position
Temperature-controlled plate
storage for delicate samples
Universal pipetting positions with
sprung locator mechanism and
raised base
Accommodates various microplate
formats, including 96, 384, flat.

Plug & play tip boxes. Stacked for twice the capacity.

More efficient use of deck space
increased walk-away processing
capacity
Eliminates sample carry-over for
sensitive applications
Choose the right tip for the job -
combi-adaptors & wide range of
tips available, including conductive
& filter

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Integrated vacuum filtration system
Plug & play installation of vacuum
chamber Vacuum activation / de-activation and pressure are completely software
controlled within SheadEASY
Versatility & freedom to work with kits
& applications from a choice of
suppliers, e.g. Millipore, Macherey-
Nagel, Qiagen, Promega

State-of-the-art sample mixing and re-suspension

Xantus uses a state-of-the-art
shaker
Quiet operation, speed control
adjustment up to 2,000RPM
Linear (up/down, left/right,
diagnonal) & circular
(clockwise/anti-clockwise) shaking
Full software-control of all shaking
parameterssuspension or sample
mixing, multiple units available

Economical storage solution and efficient utilisation of deck space allows high throughput walk-away sample processing

Fully integrated state-of-the-art microplate readers of your choice.

Fluorescence, time resolved
fluorescence, absorbance,
luminescence
Seamless software handshake
between robot & reader
Simple export of sample data from
reader to SheadEASY software
Fully automated sample
concentration adjustment,
ELISA etc.

A software controlled integrated 4-position shaker incubator. Load the plates with Xantus robotic gripper tool. A must for ELISA and cellbased assays

SheadEASY, Scheduling and Robotic Control Software Flexible Assay Composer and Task Scheduler.

Our Software is the best in its class. Renowned for simple and intuitive programming with easy to use point-and-click interfaces it offers precise and powerful commands to make work of complex liquid handling tasks easy. The software seamlessly integrates third party devices. The complete sample management including barcoding, database and generation of encrypted reports, scheduling is covered with just one toolFeatures

Windows graphical user interface
Simple to use icon-driven point & click commands
Password encrypted user levels
On-line GLP report & log file generation
Powerful advanced pipette settings
On-line sample database
Run just 1 or many samples/test.
User level definition prevents unauthorized changes
Flexible and easy to use
Graphic user interface to precisely define your application
Drag and drop concept for deck design
Pre-optimized application packages available (ELISA, EIA, RIA , IFA, Blood grouping, PCR/DNA applications etc.)

Software to automate and schedule life science applications on SIAS plattform. SheadEASY controls all the components of the robotic system, simplifying procedures from high-throughput screening to nucleic acid extraction. Its dynamic scheduler gives the system maximum flexibility and robustness.In the SheadEASY Process Manager with its Outlook style interface processes can be defined by simply dragging icons onto the workarea. After definition the user can simulate processes with the Prescheduler. The SheadEASY Explorer allows easy management of theSheadEASY database as well as configuration of all devices on the robotic system. The SheadEASY Master Control Program lets the user define and execute methods on the robotic system as well as monitoring the progress of processes via a Gantt chart. All the capabilities you need
Adding SheadEASY software to your SIAS hardware platforms allow you to automate and control your procedures like:

Assay development
Compound logistics including plate replication, predilution and serial dilution
Secondary screening
Solid phase extraction
Medium or high throughput screening
ELISA
Nucleic acid extraction
etc....

Features and functions;
Graphical setup of processes, Simulation of processes
Gantt chart for graphical representation of the progress of processes
Real dynamic scheduler (re-scheduling of processes in real time) Multilevel scheduling
Define multilayer pipette heights, allowing workdeck to be defined in different heights. example. incubator tower, pipette into different heghts same position
Continuous loading of plates
Powerful error handling features
User notifications via email, pagers, SMS
Control of multiple robots
Interface with a host computer for full remote process control
Transfer of worklists, results and logfiles, connect and import/export data from mainframe systems using common database techniques like ODBC, SQL, textfile parsing..
ActiveX interface for integration into other software systems
Many device drivers available for SIAS and 3rd party hardware e.g. washers, platereaders, sealers, labeler, barcode readers ......
Development kit for own device drivers available
Runs under Windows NT, 2000 and XP

Software controlled tablet dropper for 'just in time' preparation of tablet based reagent

s.

This created possibilities for long walk away time when staggering methods!

96 rack for flip-cap tubes

o Increase security with real-time ID tracking
o Reads barcodes on sample tubes, plates and reagents

o Selective (worklist) pipetting, or batch mode
o Decktop Plug and Play module - can be removed to
increase deck capacity when not in use.
Process and action monitoring

Safety and security options

Safety guard or optional cover
Prevents from unauthorized intervention and
protects from physical injury
Contamination protection with UV light.
Contamination protection with HEPA filter.
Emergency stop button
Active Light curtain protection

Xantus configured for ELISA tests. this setup is very compact The standard Xantus platform can be used to automate ELISA setup, and when combined with appropriate functional modules (incubator, washer and reader) can perform the complete assay. Those wishing to automate the pipetting only can choose from a range of Xantus deck sizes and options depending on the capacity requirements. However, a fully automated ELISA platform is also available. bot, based on the Sias Xantus platform, is a compact and fully automated ELISA system, designed for all applications.

The Xantus automates the complete ELISA protocol, from pipetting through incubation, washing and reading. Featuring semi-automated bar code reading of samples, plates and reagents, comprehensive software tracks sample identification from receipt to result, and enables processing by batch or by worklist. SheadEASY Dynamic Run Manager schedules the steps of each assay before the run commences, and also provide a real time update of the test/plate process sequence. Although the footprint is relatively small (width 112 cm, height 72 cm, depth 77 cm) the elisa robot accommodates 160 samples, 6 diluents and 90 reagents. Up to 4 plates can be simultaneously incubated at different temperatures, and the system can schedule and process 4-6 plates in parallel. A continuous loading function allows the user to add samples while the assay is running.

Integrated balance as an option